Anxiety Research Today is a free monthly online journal that collates and summarizes the latest research about Anxiety, including details on anxiety disorder, panic attacks, medication, counselling, therapy.

Additional evidence for the affective dimension of dyspnea in patients with COPD.

Carrieri-Kohlman V, Donesky-Cuenco D, Park SK, Mackin L, Nguyen HQ, Paul SM

Department of Physiological Nursing, University of California, San Francisco, Box 0610, 2 Koret Way, San Francisco, CA 94143-0610, USA.

The primary purpose of this secondary analysis was to determine whether 103 participants with chronic obstructive pulmonary disease rated the affective dimension of dyspnea (dyspnea-related anxiety and dyspnea-related distress) separately from the sensory dimension (intensity) during baseline exercise testing conducted as part of a randomized clinical trial. A secondary purpose was to determine if dyspnea-related anxiety and distress were rated distinctly different from other measurements of anxiety. At the end of a 6-minute walk and an incremental treadmill test, participant ratings of the magnitude of dyspnea-related anxiety and distress on the Modified Borg Scale were significantly different from their ratings of the intensity of dyspnea. Dyspnea-related anxiety and distress also appeared to be concepts independent from measures of state anxiety, negative affect, and anxiety before a treadmill test.

Published 18 January 2010 in Res Nurs Health, 33(1): 4-19.
Full-text of this article is available online (may require subscription).

Articles on Anxiety published 24 December 2009:

Anxiety prevalence and affecting factors among university students.   Asia Pac J Public Health, 22(1): 127-33.

This study provides insight into the prevalence and correlates of anxiety among university students in Bursa, Turkey. A total of 4850 students participated in the study. Students completed Spielberger's State-Trait Anxiety Inventory, as well as a questionnaire designed to determine risk factors of anxiety. About 29.6% and 36.7% of the students in the study reported state and trait anxiety scores of more than 45 points, respectively. Controlling for gender and family socioeconomic status, the ... [Abstract] [Full-text]

Articles on Anxiety published 22 December 2009:

Memories and health-related quality of life after intensive care: a follow-up study.   Crit Care Med, 38(1): 38-44.

OBJECTIVE: The overall aim of this study was to describe changes in health-related quality of life, anxiety, depression, and return to work from 0.5-1.5 yrs to 4.5-5.5 yrs after injury in patients with and without delusional memories during their intensive care unit stay. A secondary aim was to explore factors that were related to health-related quality of life and to compare trauma patients' health-related quality of life 4.5 to 5.5 yrs after injury with a reference group. DESIGN: ... [Abstract] [Full-text]

Articles on Anxiety published 21 December 2009:

The effect of preoperative heart rate and anxiety on the propofol dose required for loss of consciousness.   Anesth Analg, 110(1): 89-93.

BACKGROUND: Conflicting results have been reported on the effect of anxiety on the propofol dose required for inducing loss of consciousness (LOC). The hemodynamic effects of anxiety, increased heart rate (HR), and cardiac output may account for these discrepancies. We therefore designed this study to address, first, the effect of perioperative HR on propofol dose required for LOC and, second, the effect of perioperative anxiety on HR. METHODS: Forty-five ASA physical status I-II female ... [Abstract] [Full-text]

Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization.   J Pharmacol Exp Ther, 332(1): 298-307.

In abstinent alcoholics, stress induces negative affect-a response linked to craving and relapse. In rats, repeated stresses at weekly intervals before 5-day ethanol diet sensitize withdrawal-induced anxiety-like behavior ("anxiety") that is blocked by a corticotrophin-releasing factor 1 (CRF-1)-receptor antagonist. Current experiments were performed to identify brain sites that support CRF involvement in stress sensitization of ethanol withdrawal-induced anxiety-like behavior. First, ... [Abstract] [Full-text]

Articles on Anxiety published 18 December 2009:

Impact of two supportive care interventions on anxiety, depression, quality of life, and unmet needs in patients with nonlocalized breast and colorectal cancers.   J Clin Oncol, 27(36): 6180-90.

PURPOSE: Patients with cancer experience considerable symptom burden, psychological morbidity, and unmet psychosocial needs. Research suggests that feedback of patient-reported outcomes to clinicians or caseworkers, alongside management strategies, may result in improved patient functioning. Two intervention models were developed to test this effect in a randomized, controlled trial against usual care (UC): a telephone caseworker (TCW) model and an oncologist/general practitioner (O/GP) model. ... [Abstract] [Full-text]

Articles on Anxiety published 16 December 2009:

Phospholipase C beta 4 in the medial septum controls cholinergic theta oscillations and anxiety behaviors.   J Neurosci, 29(49): 15375-85.

Anxiety is among the most prevalent and costly diseases of the CNS, but its underlying mechanisms are not fully understood. Although attenuated theta rhythms have been observed in human subjects with increased anxiety, no study has been done on the possible physiological link between these two manifestations. We found that the mutant mouse for phospholipase C beta 4 (PLC-beta 4(-/-)) showed attenuated theta rhythm and increased anxiety, presenting the first animal model for the human condition. ... [Abstract] [Full-text]

Articles on Anxiety published 25 November 2009:

Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.   BMC Neurosci, 10: 134.

BACKGROUND: PEA-15 is a phosphoprotein that binds and regulates ERK MAP kinase and RSK2 and is highly expressed throughout the brain. PEA-15 alters c-Fos and CREB-mediated transcription as a result of these interactions. To determine if PEA-15 contributes to the function of the nervous system we tested mice lacking PEA-15 in a series of experiments designed to measure learning, sensory/motor function, and stress reactivity. RESULTS: We report that PEA-15 null mice exhibited impaired learning in ... [Abstract] [Full-text]

Depression and anxiety correlate differently with salivary free cortisol in the morning in patients with functional somatic syndrome.   Appl Psychophysiol Biofeedback, 34(4): 291-8.

Patients presenting with functional somatic syndrome (FSS) are common, and the symptoms are persistent and difficult to treat for doctors and costly for society. The aim of this study was to clarify the common pathophysiology of FSS, especially the relationship between hypothalamic-pituitary-adrenal (HPA) axis function and psychological characteristics of patients with FSS. The subjects were 45 patients with FSS and 29 healthy controls. Salivary free cortisol was measured in the morning, and ... [Abstract] [Full-text]

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