Anxiety Research Today is a free monthly online journal that collates and summarizes the latest research about Anxiety, including details on anxiety disorder, panic attacks, medication, counselling, therapy.

Enhanced anxiety follows withdrawal from subchronic exposure to phencyclidine in rats.

Audet MC, Goulet S, Doré FY

Ecole de psychologie, Université Laval, Canada; Centre de Recherche Université Laval Robert-Giffard (CRULRG), 2601 de la Canardière, F-6500, Beauport, Québec, Canada G1J 2G3.

Anxiety was assessed in rats treated with 5mg/kg of PCP bid for 7 days. One week after withdrawal, measures were collected in the light/dark apparatus and during exposure to a cat odor. PCP decreased time spent in the lit area and number of contacts with a cat collar. PCP thus amplified rats' fear of unprotected environments and predatory threats, which seems compatible with the distorted emotional experience in human schizophrenia.

Published 13 December 2006 in Behav Brain Res, 176(2): 358-61.
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